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KMID : 0377619970620110908
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Korean Jungang Medical Journal
1997 Volume.62 No. 11 p.908 ~ p.908
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Experimentally-induced intrauterine infection causes fetal brain white matter lesions in rabbits
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Yasushi, Nakamura
Koyo, Yoshida/Shigeru, Itoh/Chiharu, Yuhara/Naoki, Usui/Naoki, Mitsuhashi/Yoshinori, Kuwabara
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Abstract
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Objectives : Systemic lupus erythematosus(SLE), increases risk of fetal wastages as well as IUGR. SLE is predominantly a vascular disease, therefore, for the prenatal management of the SLE pregnancy, it should be useful to use Doppler velocimetry. The purpose of this study was to evaluate the maternal and feto-placental circulations in patients with SLE and to relate these findings to the fetal outcome.
Materials and Methods : Twenty one patients who fulfilled the diagnostic criteria of the ARA for SLE were studied. Uteroplacental flow velocity wavefoluis were obtained from the uterine artery and feto-placental flow waveforms were from umbilical artery. Equipments we used were 3.5 MHz transducer and Acuson 128XP/10. The waveforms were analyzed by resistance index(RI) in umbilical artery and by pulsatility index(PI) and presence of early-diastolic notch in uterine artery.
Results : An abnormally elevated utero-placental flow PI value was observed in 4 of the patients at mid trimester of gestation. They were all delivered light-for-date infants who included 1 case of prenatal death. On the other hand, in these cases elevated umbilical arterial flow RI value was observed at just before termination were elected.
Conclusion : An abnormal uteroplacental and fetal umbilical artery Doppler flow velocity waveforms correlate with adverse outcome in SLE patient and suggest that changes in utero-placental circulation may precede fetal circulation.
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